GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs10160456 | 1 | rs10835158 | chr11:27331770 | LGR4 | chr11:27387510-27494334:- | 0.15 | 4.23 | 2.49E-5 | Bone mineral density (paediatric, skull) |
| BRCA | cis | rs7927771 | 1 | rs10838738 | chr11:47663049 | ACP2 | chr11:47260854-47270457:- | 0.14 | 3.65 | 0.000277 | Subjective well-being |
| BRCA | cis | rs7927771 | 1 | rs10838738 | chr11:47663049 | MADD | chr11:47290927-47351582:+ | 0.14 | 4.45 | 9.56E-6 | Subjective well-being |
| BRCA | cis | rs7927771 | 1 | rs10838738 | chr11:47663049 | MYBPC3 | chr11:47352958-47374253:- | -0.14 | -4.28 | 2.0E-5 | Subjective well-being |
| BRCA | cis | rs7927771 | 1 | rs10838747 | chr11:47716324 | MADD | chr11:47290927-47351582:+ | 0.14 | 4.43 | 1.06E-5 | Subjective well-being |
| BRCA | cis | rs7927771 | 1 | rs10838747 | chr11:47716324 | MYBPC3 | chr11:47352958-47374253:- | -0.14 | -4.1 | 4.51E-5 | Subjective well-being |
| BRCA | cis | rs7927771 | 1 | rs10838748 | chr11:47716381 | MADD | chr11:47290927-47351582:+ | 0.15 | 4.66 | 3.58E-6 | Subjective well-being |
| BRCA | cis | rs7927771 | 1 | rs10838748 | chr11:47716381 | MYBPC3 | chr11:47352958-47374253:- | -0.14 | -4.12 | 4.16E-5 | Subjective well-being |
| BRCA | cis | rs7927771 | 1 | rs10838757 | chr11:47763016 | MADD | chr11:47290927-47351582:+ | 0.15 | 4.74 | 2.43E-6 | Subjective well-being |
| BRCA | cis | rs7927771 | 1 | rs10838757 | chr11:47763016 | MYBPC3 | chr11:47352958-47374253:- | -0.14 | -4.3 | 1.83E-5 | Subjective well-being |
| BRCA | cis | rs3858526 | 1 | rs10838909 | chr11:5960490 | UBQLNL | chr11:5535624-5537956:- | 0.15 | 3.48 | 0.000515 | DNA methylation (variation) |
| BRCA | cis | rs718314 | 1 | rs10842708 | chr12:26474867 | BHLHE41 | chr12:26272961-26278003:- | 0.13 | 3.68 | 0.000241 | Waist-hip ratio;Renal cell carcinoma |
| BRCA | cis | rs718314 | 1 | rs10842708 | chr12:26474867 | SSPN | chr12:26348269-26405853:+ | 0.11 | 3.57 | 0.000372 | Waist-hip ratio;Renal cell carcinoma |
| BRCA | cis | rs12303914 | 1 | rs10845106 | chr12:10472338 | KLRD1 | chr12:10457050-10469849:+ | -0.12 | -4.68 | 3.31E-6 | Thiazide-induced adverse metabolic effects in hypertensive patients |
| BRCA | cis | rs4765219 | 1 | rs10846579 | chr12:124407403 | DNAH10 | chr12:124247042-124420265:+ | 0.25 | 6.43 | 1.87E-10 | Waist-to-hip ratio adjusted for body mass index |